Mexedrone (3-methoxy-2-(methylamino)-1-(p-tolyl)propan-1-one also known as 4-MMC-MeO) is a putative stimulant and possible euphoriant of the cathinone chemical class with a potency of roughly 1/10th of that of mephedrone.mexedrone crystal effects,mexedrone erowid,n-isobutyl-hexedrone,4mmc erowid,
This compound has little to no history of human usage prior to its release in August 2015 as a newly available grey area research chemical.
It has been primarily marketed as a legal alternative to mephedrone although anecdotal reports seem to universally suggest that it is largely inferior in its recreational effects due to its weaker potency, lack of stimulation and euphoria.
It may have been developed as a result of another much more effective, but problematic mephedrone derivative, N-methoxymephedrone.
Mexedrone acts as a releasing agent of serotonin and a reuptake inhibitor for monoamine neurotransmitters serotonin, dopamine and noradrenaline
. Despite its chemical similarity to mephedrone, it lacks the dopamine and noradrenaline releasing properties, and is approximately 10-20x weaker in its reuptake inhibiting and serotonin releasing properties.
This increase in neurotransmitters provides an explanation for the euphoric and anecdotal stimulating effects induced by this experience.mexedrone crystal effects,mexedrone erowid,n-isobutyl-hexedrone,4mmc erowid,
The serotonergic activity with lack of significant dopaminergic and noradrenergic activity is similar to that of MDAI and consistent with usage reports that often state that mexedrone is more sedating than stimulating.
Due to the much lower potency (1/7 to 1/20th at different monoamine transporters) compared to mephedrone, considerably higher doses are required to achieve noticeable effects.