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HU-331

250.00750.00

The endocannabinoids present a rich system of central cannabinoid (CB1), peripheral cannabinoid (CB2), and non-CB receptor-mediated pharmacology that has stimulated research in many.HU-331 synthesis,hu-331 standard,hu-210,hu-320,Quinone.A hydroxylquinone cannabidiol analog that exhibits potent antineoplastic activity on a variety
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Description

The endocannabinoids present a rich system of central cannabinoid (CB1), peripheral cannabinoid (CB2), and non-CB receptor-mediated pharmacology that has stimulated research in many fields including memory, weight loss and appetite, neurodegeneration, tumor surveillance, analgesia, and inflammation.HU-331 synthesis,hu-331 standard,hu-210,hu-320,Quinone

HU-331 is a hydroxylquinone cannabidiol analog that exhibits potent antineoplastic activity on a variety of human cancer cell lines.

It effectively inhibits the growth of human Raji and Jurkat lymphoma cells in vitro with an EC50 of approximately 0.2 µg/ml and an EC80 of 1.56 µg/ml. HU-331 also inhibits the growth of HT-29 colon carcinoma cells, which have been inoculated into nude mice, by more than 50% at a dose of 5 mg/kg.

HU-331 is a quinone anticarcinogenic drug synthesized from cannabidiol, a cannabinoid in the Cannabis sativa plant.

It showed a great efficacy against oncogenic human cells. It does not cause arrest in cell cycle, cell apoptosis or caspase activation.

HU-331 inhibits DNA topoisomerase II even at nanomolar concentrations, but has shown a negligible effect on the action of DNA topoisomerase I. AM 2201

The cannabinoid quinone It is a very specific inhibitor of topoisomerase II, compared with most known anticancer quinones.

One of the main objectives of these studies is the development of a new quinone derived compound that produces anti-neoplastic activity while maintaining low toxicity at therapeutic doses.

Synonyms
  • ​Cannabidiol Hydroxy Quinone
  • Cannabidiolquinone
  • CBDHQ
  • CBDQ

HU-331 synthesis,standard,hu-210,hu-320,Quinone

Technical Information
Formal Name
3-hydroxy-2-[(1R,6R)-3-methyl-6-(1-methylethenyl)-2-cyclohexen-1-yl]-5-pentyl-2,5-cyclohexadiene-1,4-dione
CAS Number
137252-25-6
Molecular Formula
C21H28O3
Formula Weight
328.5
Purity
≥95%
Formulation
A crystalline solid
SMILES
CCCCCC1=CC(=O)C(=C(O)C1=O)[C@@H]1C=C(C)CC[C@H]1C(=C)C
InChi Code
InChI=1S/C21H28O3/c1-5-6-7-8-15-12-18(22)19(21(24)20(15)23)17-11-14(4)9-10-16(17)13(2)3/h11-12,16-17,24H,2,5-10H2,1,3-4H3/t16-,17+/m0/s1
InChi Key
WDXXEUARVHTWQF-DLBZAZTESA-N
Shipping & Storage Information

Storage-80°C

Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 1 year

Additional information

Weight N/A
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